What we should know about bifurcation disease.
نویسنده
چکیده
ith great interest we read the article by Li et al. (1) regarding asomotor functional responses of a conduit coronary artery distal o sirolimus-eluting stents in a porcine model. The researchers tated in the discussion, “. . .most of the drug taken up into cardiac issue was transferred by direct contact with the arterial wall, which ay have served as a reservoir for subsequent transfer via diffusion, r the vasa vasorum” (1). However, we have previously reported hat tissue sirolimus levels of proximal/distal vessel, stented myoardium, and proximal/distal myocardium were much lower (less han 2%) than the stented vessel area concentration (peaked at 1 ay after stent implantation [14.5 10.9 ng/ml]). Moreover, irolimus was not detected in either the proximal or distal yocardium at 30 days (2). Therefore, even low sirolimus concenrations with short duration may affect vasomotor function.
منابع مشابه
What every pediatrician should know about liver transplantation
Liver transplantation is the treatment of choice for children with end-stage liver disease. Improvement in outcomes (allograft and patient survival) has led to widespread use of pediatric LT worldwide. This success is due to improvement in patient selection, transplant surgery, anesthesia/postoperative care and immunosuppression management. This review will focus on different aspects of LT whi...
متن کاملP-138: What Should We Know about Ethical Problem in ART? A Study of Systematic Review
Background: Advances in medical technology have had major impacts on human reproduction. The development of effective contraceptive methods has reduced unwanted fertility, and the development of a variety of drugs and procedures has, for the first time, permitted women with fertility problems to reasonably expect that they can fulfill their desires to have children. So, The aim of this review a...
متن کاملDiagnostic and therapeutic challenges for dermatologists: What shall we do when we don’t know what to do?
What shall we do when we have done everything we could for the diagnosis and treatment of a patient, but were not successful? What shall we do when there is no definite treatment for a patient? What shall we do when we have no diagnosis or treatment for a patient? Some useful suggestions are presented here to get rid of these situations.
متن کاملWolves and Big Yellow Taxis: How Would Be Know If the NHS Is at Death’s Door? Comment on “Who killed the English National Health Service?”
Martin Powell suggests that the death of the English National Health Service (NHS) has been announced so many times we are at risk of not noticing should it actually happen. He is right. If we ‘cry wolf’ too many times, we risk losing sight of what is important about the NHS and why.
متن کاملMolecular approaches to diagnosis of invasive aspergillosis what we know and what we do not know.
Invasive aspergillosis (IA) are a major complication in immunocompromized patients where can be serious and rapidly fatal. Early diagnosis and early appropriate antifungal treatment is important in reducing mortality and morbidity. But despite many efforts to develop detection methods, the diagnosis of IA still remains challenging and current conventional methods are limited for adequate diagno...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- JACC. Cardiovascular interventions
دوره 1 5 شماره
صفحات -
تاریخ انتشار 2008